| abstract |
Invention Patent: <B> "DIRECTION OF PRO - MACROMOLECULAR DRUGS FOR T LYMPHOCYTES" <D>. Composition for intracellular release of a chemical agent to a T cell, comprising a receptor binding and endocytosis-inducing ligand and a chemical agent coupled to a water-soluble polymer. The ligand binds to a receptor on T lymphocytes causes the composition's endositosis. The composition also includes a spacer for coupling the chemical and binding agent to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, markers, antigens, drugs and others. A preferred water-soluble polymer is a copolymer of N- (2 - hydroxypropyl) methacrylamide (HPMA). The composition can also comprise a carrier, such as a water-soluble polymer, liposome or particles. Methods for using these compositions for the delivery of a chemical agent in vivo or in vitro are also presented. |