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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
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filingDate 1997-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4cd6724855ee3efafdba9774b8e3e2d
publicationDate 2000-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-9708660-A
titleOfInvention Phosphorous organo compound
abstract Invention Patent: <B> "PHOSPHORUS ORGAN COMPOUND" <D>. Organo phosphonic acids containing the formula are disclosed where: n = 0 or 1 R ~ 1 ~ = H or R ~ 2 ~ = R ~ 3 ~ = R ~ 4 ~ = H or CH ~ 3 ~ which provide improved drug bioavailability and nutrients by permeabilization of cell membranes. The products are prepared by reacting a long-chain aliphatic acid chloride containing 10-20 carbon atoms with an alkyl phosphonic acid derivative containing an active amino group or hydroxy group active in chloroform at temperatures below 5 ° C . Especially useful are the reaction products of palmitoyl or lauroyl chloride with ethane-1-hydroxy-1, 1-diphosphonic acid, 2-amino-ethyl-phosphonic acid or 1-amino-ethyl-phosphonic acid.
priorityDate 1996-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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