| abstract |
the present invention relates to new 4- or 5-aminosalicylic acid derivatives and to a pharmaceutical composition containing these 4- or 5-aminosalicylic acid derivatives as the active ingredients, useful for the treatment of intestinal diseases such as inflammatory heart disease intestine (ibd) and irritable bowel syndrome (ibs) and for the prevention / treatment of colon cancer. more specifically, these derivatives comprise a hydrogen sulfide release moiety linked via an azo bond, an ester, an anhydride, a thioester or an amide bond to a 4- or 5-aminosalicylic acid molecule. furthermore, the present invention provides a process for preparing these compounds and using them for the treatment of ibd and ibs and the prevention and treatment of colon cancer. |