TETRACYCLINE COMPOUNDS AND ANALOGUES THEREOF, USE OF SUCH COMPOUNDS, PHARMACEUTICAL COMPOSITION, AS WELL AS SYNTHESIZATION AND PREPARATION METHODS OF SUCH COMPOUNDS
The present invention relates to the tetracycline class of antibiotics and has played a large role in the treatment of infectious diseases in the last 50 years. However, the widespread use of tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of described tetracycline and tetracycline analogues provides an efficient and enantioselective pathway to a variety of tetracycline and polycycline analogues previously inaccessible through prior tetracycline syntheses and semi-synthetic methods. These analogs can be used as antimicrobial agents or antiproliferative agents in the treatment of diseases of humans or other animals.