| abstract |
"MULTIMERIC PROTEIN STRUCTURE AND PROCESS FOR PREPARATION OF MULTIMERIC PROTEIN STRUCTURE", discloses herein multimeric protein structures comprising at least two alpha-galactosidase monomers that are covalently linked to each other through a linking group, as well as a process for preparing said structures, and methods of treating Fabry disease by administering a multimeric protein structure; the disclosed multimeric protein structures show improved performance, in terms of improved activity and/or longer duration activity under lososomal conditions and a serum environment. |