| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e291a6de0730dfbe3c9f3610b5f2838 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 |
| filingDate |
2021-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a20392785c41fb2323c011cd6cfde79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3539e6847ebc45e1356486190428292e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51258c7aa095735b17cc6d9944034562 |
| publicationDate |
2023-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112022020956-A8 |
| titleOfInvention |
LONG-ACTING TYROSINE PEPTIDE TYROSINE (PYY) ANALOGS AND METHODS OF USE |
| abstract |
This invention relates to isolated polypeptides that are long-acting analogues of human PYY. The disclosed PYY analogue polypeptides have beneficial physicochemical properties over endogenous PYY and known synthetic PYY analogue polypeptides, such as longer elimination half-lives (i.e., prolonged action) (t1/2) and improved solubility and thermal stability . This invention also relates to methods of using the presently disclosed PYY analog polypeptides in a variety of therapeutic indications, as well as methods of making the same. The disclosed PYY analogue polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as type 2 diabetes, treating obesity and providing weight loss, and in methods of treating non-alcoholic fatty liver disease (NAFLD) and /or non-alcoholic steatohepatitis (NASH). |
| priorityDate |
2020-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |