| abstract |
ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS. The present invention relates to aryl piperidine compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates and stereoisomers thereof, pharmaceutical compositions containing them, and methods of using them, including methods for treating disease states, disorders, and conditions associated with modulation of MGL, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to, major depressive disorder, treatment-resistant depression, anxiety depression, autism, Asperger's syndrome, bipolar disorder), cancers and eye conditions: ; wherein R2a, R2b, R3 and R4 are as defined herein. |