| abstract |
rifabutin treatment methods, uses and compositions. a rifabutin formulation produced from a rifabutin powder in the presence of an acid, water and a suitable solvent to promote dissolution of the rifabutin. a method of preparing a rifabutin formulation, the method comprising: preparing a solution comprising a solvent, water and an acid; and adding said solution to the rifabutin powder, thereby causing the rifabutin to dissolve in the solution. a method of preparing a rifabutin formulation, the method comprising: preparing a solution comprising water and an acid; and adding said solution to a solution of rifabutin in a solvent, thereby producing an aqueous formulation of rifabutin. a method of treating a bacterial infection in a subject, the method comprising administering a therapeutically effective amount of rifabutin in an injectable formulation or by inhalation. |