| abstract |
long-lasting formulation containing rivastigmine and method of preparing the same. The present invention relates to a sustained release microsphere for long term injectable formulations comprising one or more active ingredients selected from the group consisting of rivastigmine and poorly soluble pharmaceutically acceptable salts thereof and a biodegradable polymer, and an injectable formulation of long-term treatment for preventing or treating Alzheimer's disease comprising the same and a method for preparing the microsphere, and it can reduce the side effects of the patient's gastrointestinal tract, which are often seen in conventional oral administration agents, and increase the adaptability of taking the drug, thus maximizing the therapeutic effect, by providing a long-lasting injectable formulation comprising a sustained-release microsphere of rivastigmine, which has a high content while effectively controlling the initial rapid release of the drug. |