| abstract |
substituted benzyl triazole compounds for inhibiting cbl-b and other uses thereof. The present invention relates to compounds of formula (I), compositions and methods for use in inhibiting the e3cbi-b enzyme in the ubiquitin proteasome pathway. the compounds, compositions and methods can be used to modulate the immune system, to treat diseases modifiable by the immune system, and to treat cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a cbi-b inhibitor and a cancer vaccine, and pharmaceutical compositions comprising a cbi-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a cbi-b inhibitor and an oncolytic virus. |