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filingDate 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1289cc588dae7ba8e303df460a77b7fd
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publicationDate 2022-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-112021023952-A2
titleOfInvention Methods of rejuvenating aged tissue by inhibiting 15-hydroxyprostaglandin dehydrogenase (15-pgdh)
abstract methods of rejuvenating aged tissue by inhibiting 15-hydroxyprostaglandin dehydrogenase (15-pgdh). the present invention relates to compositions and methods based on the identification of 15-hydroxyprostaglandin dehydrogenase (15-pgdh) as a therapeutic agent in aging, muscular dystrophy to improve muscle atrophy, increase muscle mass, function and strength. Compositions and methods for rejuvenating an aged fabric are provided herein. in particular, 15-pgdh inhibitors such as sw033291 are used to elevate prostaglandin e2 (pge2) levels in muscle or tissue.
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