| abstract |
specific inhibitors of tgf-beta ltbp complexes and uses thereof. described herein are inhibitors, such as antibodies, and antigen binding portions thereof, which selectively bind to ltbp1-tgfß and/or ltbp3-tgfß complexes. the application also provides methods of using these inhibitors to, for example, inhibit tgfß activation and treat individuals suffering from tgfß-related disorders, such as fibrotic conditions. methods of selecting a context-dependent or context-independent isoform-specific tgfß inhibitor for an individual in need thereof are also provided. |