| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2276405ae0e23cfcd15651de21c8565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e9bca1120ab9d2f65b138f53e3eda4d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-00 |
| filingDate |
2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5800163c69e315b483a0efe15e669a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09cce4dfc5e69e4a8a24a6353e947b87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b81540f1781e749eb3f4d16622365040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c87e9fdfb44c168fe315e9ade05bcdc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85c94c38b5b8a2a1f0e27d9d99cea916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cbad1ac120f5e24fcee5bfc92d64972
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c070f0f5dc15d13af3226c3df04b99e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ccef0686be484ce89479f81cc22a12f |
| publicationDate |
2021-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112021011898-A2 |
| titleOfInvention |
FUSION PROTEIN INCLUDING VARIANTS OF LEFTY TO HUMAN PROTEIN AND USE THEREOF |
| abstract |
FUSION PROTEIN INCLUDING VARIANTS OF LEFTY TO HUMAN PROTEIN AND USE THEREOF.nThe present invention relates to a human Lefty A protein variant with improved productivity and stability, a fusion protein comprising the protein variant, and a composition for preventing and/or treating neuromuscular disease comprising the protein variant or the fusion protein. . In accordance with the present invention, a human Lefty A protein variant and a fusion protein comprising the variant are constructed which have better stability than the naturally occurring human Lefty A protein, and thus are expressed at high levels and produced in high yield in animal cells. Furthermore, administration of the human Lefty A protein variant or constructed fusion protein can restore nerve and motor functions in animal models of nerve disease. Consequently, the use of the human Lefty A protein variant or fusion protein can effectively prevent or treat various nerve diseases and muscle diseases. |
| priorityDate |
2018-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |