abstract |
The present invention relates to certain 2-oxoquinazoline derivatives of formula (ia): (ia) which are inhibitors of methionine adenosyltransferase 2a (mat2a). pharmaceutical compositions comprising such compounds and methods of treating diseases treatable through inhibition of mat2a, such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (mtap) are also described. |