http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112021009543-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2458-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-8831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6815 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-7233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2020-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c305b5d088ada189496a2d41fb46b0da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ee7dc6e725016867c28a3bb24f10049 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ece7130b752d54776a487c657238aa3 |
| publicationDate | 2021-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112021009543-A2 |
| titleOfInvention | methods for identifying free thiols in a protein drug, identifying disulfide heterogeneity in a protein drug, and selecting a protein drug, and pharmaceutical composition |
| abstract | methods for identifying free thiols in a protein drug, identifying disulfide heterogeneity in a protein drug, and selecting a protein drug, and, pharmaceutical composition. compositions and methods for identifying free thiols in proteins are provided. an exemplary method of tagging peptides with a tag to identify free thiols and a tag to identify native disulfide bonds and parse the tags using targeted ms². in one embodiment, the method provides complete coverage of all 32 cysteine residues in an igg molecule. in other embodiments, the method spans the 16 cysteine residues in the heavy and light chains in an igg molecule. in another embodiment, the method spans the 5 cysteine residues in each light chain of an igg molecule. in another embodiment, the method spans the 11 cysteine residues in each heavy chain of an igg molecule. |
| priorityDate | 2019-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.