| abstract |
fusion protein and use thereof. a fusion protein is provided, comprising a first binding domain that specifically binds to a tumor associated antigen and a second binding domain that specifically binds to a cd47 protein, wherein the second binding domain comprises a mutant of a variant 1 of human sirpa. also provided are an immunoconjugate, nucleic acid molecules, vectors, compositions and cells related to the fusion protein and their methods of preparation and their uses in the preparation of drugs. |