| abstract |
dual-action cd1d immunoglobulin. the present invention relates to the field of immunology, more in particular to the field of binding fractions and/or immunoglobulins that bind to human cd1d, including antibodies and fragments thereof that modify biological functions mediated by cd1d, such as enhanced activation and reduced activation of cd1d-restricted T cells, including natural killer T cells and gamma-delta T cells, and modulating the function of cells expressing cd1d. the invention also relates to bi-, tri or multispecific immunoglobulins that bind to cd1d and a tcr gamma-delta and/or a tumor target. the invention further relates to pharmaceutical preparations and the use of such mono-, bi-, and tri- or multispecific binding moieties and/or immunoglobulins in the treatment of diseases or disorders. |