| abstract |
provided herein are modified nucleic acids (e.g., expression vectors, including viral vectors such as lentiviral vectors, adenoviral vectors, aav vectors, herpes viral vectors, and retroviral vectors) that encode oct4; klf4; sox2; or any combination thereof which is useful, for example, in inducing cell reprogramming, tissue repair, tissue regeneration, organ regeneration, reversal of aging, or any combination thereof. also provided herein are recombinant viruses (e.g., lentivirus, alphavirus, vaccinia virus, adenovirus, herpes virus, retrovirus, or aavs) comprising the modified nucleic acids (e.g., modified nucleic acids), modified cells, compositions comprising the nucleic acids modified, recombinant virus, modified cells, modified proteins, chemical agents that are capable of activating the expression of oct4; klf4; sox2; or any combination thereof, a modified protein selected from the group consisting of oct4; klf4; sox2; or any combination thereof, an antibody capable of activating oct4 expression; klf4; sox2; or any combination thereof and methods of treating a (e.g. eye disease), preventing a disease (e.g. eye disease), regulating (e.g. induction or induction and then stopping), cellular reprogramming, regulation of tissue repair, regulation of tissue regeneration, or any combination thereof). |