| abstract |
"INHIBITING INTEGRINA avß6"nThese are small molecule avß6 integrin inhibitors and methods of using them to treat a range of diseases and conditions. Applicants found novel αv6 integrin inhibitor compounds and evaluated the size, performance and usefulness of representative examples of such compounds, both with respect to biochemical potency (eg, using the assay of Example 35 to assess polarization assays of fluorescence of avß6 binding compounds) for in vitro permeability properties (for example, using the assay of Example 36 to assess MDCK permeability). |