abstract |
"T CELL MODIFICATION". The present invention relates to improved compositions and methods for treating diseases, such as cancer, by providing a cell immunotherapy, wherein the cell immunotherapy is an immunomodulatory cell expressing an exogenous CD8 coreceptor and a T cell receptor. modified (TCR). The invention further relates to polynucleotides, expression vectors, and immunomodulatory cells comprising immunotherapy, as well as methods of generating said immunomodulatory cells. |