| titleOfInvention |
bispecific antibody, isolated nucleic acid molecule, vector, host cell, method of preparing the bispecific antibody, conjugate, kit, use of the bispecific antibody and pharmaceutical composition |
| abstract |
bispecific antibody, isolated nucleic acid molecule, vector, host cell, method for preparing the bispecific antibody, conjugate, kit, use of the bispecific antibody, and pharmaceutical composition. the present invention relates to the field of tumor treatment and molecular immunology and specifically to a bifunctional anti-vegfa/pd-1 antibody, a pharmaceutical composition thereof and use thereof. specifically, the bifunctional anti-vegfa/pd-1 antibody comprises a first functional region of protein targeting vgefa and a second functional region of protein targeting pd-1. the bifunctional antibody of the present invention can specifically bind to vegfa and pd-1, and inhibit tumor-induced angiogenesis, thus having a good application perspective. |