| abstract |
use of a composition comprising igf-2 receptor specific agonist ligand, compound or a pharmaceutically acceptable salt thereof, and composition. provided are methods of treating neurodevelopmental disorders, such as angelman syndrome and autism, comprising administering to a subject a composition comprising an igf-2 receptor agonist ligand. the igf-2 receptor agonist ligand can be igf-2, or mannose-6-phosphate, or a derivative thereof. compositions comprising mannose-6-phosphate derivatives are also described. |