| abstract |
1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor and pharmaceutical composition comprising them. the present invention relates to innovative compounds that have a histone deacetylase 6 (hdac6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof and a method for preparing them. according to the present invention, innovative compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have histone deacetylase 6 (hdac6) inhibitory activity, and are effective in the prevention or treatment of diseases related to hdac6, which include diseases infectious; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; adnexal diseases of the eye and ocular; circulatory diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; and teratosis or deformities, and chromosomal aberration. |