| titleOfInvention |
ISOLATED ANTIGEN BINDING PROTEIN, ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME, COMPLEX, METHOD TO PRODUCE AN ANTIGEN BINDING PROTEIN, ANTIGEN, ANTIGEN, HYDROTHEYTHEATING, POLYTHEOLOGY, HYDROTHEYTHEATING PROTEIN KIT, PHARMACEUTICAL COMPOSITION, CONTAINER OR INJECTION DEVICE, AND METHOD FOR TREATING OR PREVENTING DISEASES |
| abstract |
ISOLATED ANTIGEN BINDING PROTEIN, ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME, COMPLEX, METHOD TO PRODUCE AN ANTIGEN BINDING PROTEIN, ANTIGEN, ANTIGEN, HYDROTHEYTHEATING, POLYTHEOLOGY, HYDROTHEYTHEATING PROTEIN KIT, PHARMACEUTICAL COMPOSITION, CONTAINER OR INJECTION DEVICE, AND METHOD FOR TREATING OR PREVENTING DISEASES. The present invention provides antibodies and antigen-binding fragments (e.g., human antibodies) that specifically bind to the human IL-36 receptor. Methods to treat or prevent IL36R-mediated diseases (for example, inflammatory skin or colon conditions, such as palmoplantar pustular psoriasis, palmoplantar pustulosis, generalized pustular psoriasis, ulcerative colitis or IBD) using the antibodies and fragments are also provided, together with methods of producing antibodies and fragments. |