abstract |
NAFTHYRIDINONE COMPOUNDS REPLACED USEFUL AS T-CELL ACTIVATORS The present invention relates to compounds of Formula (I) or a salt thereof, wherein: R1, R2, R3, R4, R5 and m are defined herein. They also refer to methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alfa (DGKalfa) and diacylglycerol kinase zeta (DGKzeta) and pharmaceutical compositions comprising such compounds. The compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. |