| abstract |
The invention provides a polymyxin compound of the formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of the formula (I) and the use of the compounds and compositions in treatment methods, such as methods for treatment of microbial infections. The compounds of the formula (I) are represented as follows: where -R15 is a group: and -R16 is hydrogen; -R17 is hydrogen; -L- is a covalent or methylene bond; andn-Ar is optionally substituted aryl. The groups -X-, -R1, -R2, -R3, -R4 and -R8 are as defined here. |