| abstract |
HEMAGLUTININ MUTANTS OF THE INFLUENZA VIRUS. The present invention relates to the production of modified influenza viral proteins in plants. More specifically, the present invention relates to the production and increased production of Influenza virus-like particles (VLP) in plants, wherein the VLPs comprise the modified Influenza viral proteins, such as modified Influenza hemagglutinin (HA). The HA protein can comprise an amino acid sequence comprising at least one substitution when compared to a corresponding wild type amino acid sequence. In addition, nucleic acids encoding the modified HA protein are provided. In addition, methods of producing an Influenza virus-like particle (VLP) and methods of increasing the yield of producing an Influenza virus-like particle (VLP) in a plant, portion of a plant or plant cell are also provided. . |