| abstract |
the invention relates to derivatives of 4- (1-hydroxy-3,4-dihydro-1hbenzo [c] [1,2] oxaborinin-3-yl) benzimidamide and its use in the treatment of diseases and skin conditions (for example , netherton's syndrome, rosacea, atopic dermatitis, psoriasis and itching) caused by abnormally high levels of protease activity (particularly serine proteases, such as kallikreins). moreover, the invention relates to compositions containing the derivatives and processes for their preparation. |