| abstract |
the invention provides nucleic acids encoding acid α-glycosidase (gaa). in certain embodiments, nucleic acids have more than about 86% sequence identity to a sequence selected from the group consisting of any of the sequences established as sequences: 1-5. in certain embodiments, nucleic acids encoding acid Î ± -glycosidase (gaa) contain less than 127 cpg dinucleotides. expression cassettes, vectors, cells and cell lines and methods of using such nucleic acids encoding acid α-glycosidase (gaa) are also provided. |