| abstract |
'' NUCLEIC ACID TO TREAT ALLERGY TOn MITES".n[Problem] To provide a nucleic acid that is expected to be usefulnto treat dust mite allergy. [Means to be resolved] Annucleic acid comprising a nucleotide sequence that encodesna chimeric protein, wherein the nucleic acid comprises a sequencen nucleotide encoding a signal peptide, a sequence ofnnucleotide that encodes an intraorganelle stabilization domain ofnLAMP, a nucleotide sequence that encodes an allergen domainncomprising Der p 1, Der p 2, Der p 23 and Der p 7, a sequence ofnnucleotide encoding a transmembrane domain and a sequence ofnnucleotide that encodes a targeting domainnendosomal / lysosomal LAMP in this order. |