| abstract |
"MULTIVALENT ANTIBODY"nThe invention relates to a multivalent antibody comprising: a base antibody moiety comprising two binding domains; and at least one additional binding domain, the base antibody portion being connected by a linker to at least one additional binding domain, each binding domain of the base antibody portion and each of at least one of the domains Additional linkers all have a common variable region, and the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody comprising: a base antibody portion comprising two binding domains; and at least one additional binding domain, at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, which connects a variable region of the base antibody portion and the CH1 region, and the multivalent antibody binding to at least three different epitopes. |