BINDING MOLECULES AND ISOLATED NUCLEIC ACID, VECTOR, HOSTING CELL, METHODS TO PRODUCE THE BINDING MOLECULE, TO TREAT AN INDIVIDUAL WITH CANCER AND TO POSITIVELY REGULATE OR EXTEND THE ACTIVITY OF CÉLES DE CÉLULOS
The invention relates to 4-1BB agonists targeting Her2, in particular antigen-binding molecules containing the 4-1BBL trimer comprising at least one antigen-binding domain capable of specifically binding to Her2; and their use in cancer treatment, as well as their use in combination with bispecific T-cell activation anti-CD3 antibodies.