abstract |
The present invention relates to N- (phenyl) -2- (phenyl) -pyrimidine-4-carboxamide derivatives and related compounds of formula I as inhibitors of HPK1 (hematopoietic progenitor kinase 1) to treat cancer, such as example, breast cancer, colorectal cancer, lung cancer, ovarian cancer and pancreatic cancer. Preferred compounds are, for example, N- (5-Fluoro-2- (2pyridin-2-yl) pyrrolidin-1-yl) phenyl) -2- (2-fluoro-6-methoxyphenyl) pyrimidine-4-carboxamide - (5-Fluoro-2- (hexahydropyrrolo [3,4-b] pyrrole-1 (2H) -yl) phenyl) -2- (2-fluoro-6-methoxyphenyl) pyrimidine-4-carboxamide.n (I) |