| abstract |
The present invention relates to variants of human interleukin 15 (IL-15) that have therapeutic and diagnostic uses and methods for obtaining them. The present invention also provides fusion proteins that comprise a variant of human IL-15. Methods are also provided to stimulate or suppress immune responses in a mammal and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of these IL-15 variants. |