| abstract |
the present invention relates to a new artificial triple chain antibody comprising three polypeptide chains, wherein a first polypeptide chain comprises a first heavy chain variable domain, a second polypeptide chain comprises a first light chain variable domain that is paired with the first heavy chain variable domain to form a first antigen binding site; and a third polypeptide chain comprises a second single domain antigen binding site and a third single domain antigen binding site. the present invention also provides a polynucleotide encoding the triple chain antibody, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, an immunoconjugate comprising the triple chain antibody and a pharmaceutical composition comprising the triple chain antibody or its immunoconjugate and use of the triple chain antibody in immunotherapy, disease prevention and / or diagnosis. |