| abstract |
It is a polypeptide that has an amino acid sequence corresponding to a binding domain of a botulinum toxin. The polypeptide modulates the expression of genes involved, for example, in collagen production and extracellular matrix organization, and therefore is useful in treating or reducing the occurrence of a disease, such as an ECM disease, an epithelial tissue disease. or connective, an endothelial disease or a fibrotic disease, for example, a fibrotic disease of the ECM, connective tissue or endothelium. Acids encoding the polypeptide, as well as vectors, host cells, and systems that comprise the nucleic acids are also described. |