| abstract |
the present invention relates to polypeptides that are covalently linked to non-aromatic molecular frameworks, such that two or more peptide loops are subtended between attachment points to the framework. in particular, the invention describes peptides that are high-affinity binders for the eph a2 tyrosine kinase receptor (epha2). the invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and / or functional groups, pharmaceutical compositions comprising said peptide ligands and drug conjugates and the use of said peptide ligands and drug conjugates for prevent, suppress or treat a disease or disorder characterized by overexpression of epha2 in diseased tissue (such as a tumor). |