| abstract |
the present patent application describes therapies that can modulate (e.g., increase) the proliferation, survival, activation and / or function of treg cells. in some modalities, the modulation is selective or specific for treg cells. the present patent application provides muteins of il-2, compositions comprising them and methods for using them. in another aspect, the embodiments provide compositions, for example, pharmaceutically acceptable compositions, which include a therapeutic compound (yl-2 mutein) described herein, formulated in conjunction with a pharmaceutically acceptable carrier. a kit comprising a therapeutic compound described herein is also within the scope of the present invention. |