| abstract |
the present invention relates to polypeptides that contain an antigen binding domain and a carrier moiety that has an inhibitory domain that inhibits the antigen binding activity of the antigen binding domain and that has a longer half-life than that of the antigen-binding domain that exists individually; methods for producing and screening polypeptides; pharmaceutical compositions comprising the polypeptide, methods for producing and screening for an antibody with a single domain whose antigen binding activity is inhibited through its association with a particular vl, vh or vhh; and fusion polypeptide libraries that include an antibody with a single domain whose antigen binding activity is inhibited through its association with a particular vl, vh or vhh. |