http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112020010180-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b78c620d1d3cadeaae214bffb2de6b5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1729 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 |
| filingDate | 2018-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1280e6773f268607e3a52a7c441034 |
| publicationDate | 2021-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112020010180-A2 |
| titleOfInvention | B-DEFENSIN AND / OR A-HUMAN DEFENSIN FOR USE IN PREVENTING OR TREATING GRAFT DISEASE AGAINST ACUTE HOST |
| abstract | The present invention relates to methods for treating and / or preventing acute as well as chronic graft versus host disease (GVHD), and, in particular, to methods for decreasing mortality and especially increasing long-term survival; acute complications associated with GVHD such as diarrhea, weight loss and sepsis based on normalization of intestinal, liver, lung and skin microbiota and mucosal defense; rebalancing of the immune system with normalization of cytokine production of IFN-¿, TNF-a, Il-4, IL-5, IL-6, IL-8, IL-9, IL-10 and IL-13 and prevention and / or cytokine storm treatment; chronic complications associated with GVHD, such as bronchiolitis obliterans and scleroderma, the method comprising oral, subcutaneous, intrapulmonary and / or dermal / transdermal administration of one or more mammalian defensins selected from the group of a- and ß-defensins in a patient who received or is about to receive an allogeneic hematopoietic stem cell transplant. |
| priorityDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 419.