| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-66 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 |
| filingDate |
2018-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_804b67e38b1c5694e8d366794fd7fdef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9efbe02d62f4bad20b140ca8a44ba4a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeff5b4e3ae70f820bd1fedc87b75f0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_415751070cb411165710798d1bf6ff8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11b7c72f535353bf122b5a481ac9d06c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cec5b17f2f1cb3d43a95785557e6f03 |
| publicationDate |
2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112020007154-A2 |
| titleOfInvention |
method for producing a heterodimeric polypeptide and polypeptides |
| abstract |
the present invention discloses a method for the generation of multispecific antibodies by an antibody medium exchange reaction between two 2/3 iggs (2/3-iggs) destabilized in one half by asymmetric disturbing mutations, promoting the generation of bispecific antibodies of total length correctly assembled. the method can be carried out in the absence of reducing agents and does not require disulfide connections in the hinge region at the 2/3 -iggs starting. |
| priorityDate |
2017-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |