| abstract |
the present invention relates to methods of treating a disease associated with ciliopathy, including administering to a subject in need of an effective amount of a compound that targets at least one receptor coupled to the g protein. methods for identifying therapeutic agents for the treatment of a disease that has a ciliopathy, including providing an animal model system of the ciliopathy to test a suspected therapeutic agent; administer a disruptive agent to the animal, treat the animal administered with the alleged therapeutic agent, compare the measurable phenotype of the treated animal with that of the untreated animal, and identify the therapeutic target for the treatment of a ciliopathy, when the measurable phenotype of the treated animal is reduced when compared to that of the untreated animal. |