| abstract |
n- (6 - (((2r, 3s) -3,4-dihydroxy butan-2-yl) oxy) -2 - ((4-fluoro benzyl) thio) pyrimidin-4-yl) -3-methylazetidine -1- sulfonamide (compound 4), a known chemokine modulator, in combination with colchicine is useful in the treatment of diseases / conditions in which modulation of chemokine receptor activity, interleukin-1 (il-1) activity and / or myeloperoxidase (mpo) activity is beneficial. in particular, compositions and methods for the treatment and prevention of such diseases / conditions are provided herein. compound 4 |