| abstract |
among other things, the present disclosure provides technologies to modulate beta-catenin functions. in some embodiments, the present disclosure provides stapled peptides that interact with beta-catenin. in some embodiments, the stapled peptides supplied interact with beta-catenin at a beta-catenin axin-binding site. in some embodiments, the present disclosure provides compounds, compositions and methods for preventing and / or treating conditions, disorders and diseases that are associated with beta-catenin. |