| abstract |
the present invention relates to the compounds of the formula (i): formula (i) in which q is selected from o or s; r1 is an optionally substituted, saturated or unsaturated hydrocarbyl group, optionally including one or more n, o or s heteroatoms; and r2 is a cyclic group substituted in position a by a monovalent heterocyclic group 10 or a monovalent aromatic group, wherein a ring atom of the heterocyclic or aromatic group is directly attached to the ring atom of the cyclic group, where the heterocyclic or the aromatic group can optionally be substituted and in which the cyclic group can optionally be additionally substituted. the present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds and to the use of such compounds in the treatment and prevention of medical disorders and diseases, mainly by inhibiting nlrp3. |