http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-112020002647-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6d904c14ea701a3c2e2a9d5592349e9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8269 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8213 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 |
| filingDate | 2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cd4ef0ac5769408ffa24dfdc7ba647b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b4e72624f751977d659cbf67fb45dc1 |
| publicationDate | 2020-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-112020002647-A2 |
| titleOfInvention | compositions and methods for genome modification |
| abstract | Compositions and methods for modifying genomic DNA sequences are provided. the methods produce double-strand breaks (dsbs) at predetermined target sites in a genomic DNA sequence, resulting in mutation, insertion and / or deletion of dna sequences at the target site (s) in a genome. the compositions comprise DNA constructs comprising nucleotide sequences that encode a cms1 protein operably linked to a promoter that is operable in the cells of interest. DNA constructs can be used to target genomic DNA modification at predetermined genomic sites. The methods for using these DNA constructs to modify genomic DNA sequences are described here. in addition, compositions and methods for modulating gene expression are provided. the compositions comprise dna constructs comprising a promoter that is operable on cells of interest operably linked to nucleotide sequences encoding a mutated cms1 protein with an ability to produce abolished dsbs, optionally linked to a domain that regulates transcriptional activity. the methods can be used to regulate up or down the expression of genes in predetermined genomic sites. |
| priorityDate | 2017-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1055.