| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4328a919e437970c81607f40f832542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52aacee4ea835e1ad6b30c413669c0da |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-2315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70596
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-70517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd64215e17c143e573ebb4d5a4323c7b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_062d7f53bee07b068ad464b67465b6bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5219a1db64e9d6b149a4c916c3a4b5bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef8a54c12093998c15a45e017ddfd6d6 |
| publicationDate |
2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-112019024291-A2 |
| titleOfInvention |
use of cd39 and cd103 for the identification of reactive human tumor t cells for the treatment of cancer |
| abstract |
the present invention relates to methods for treating a subject bearing a tumor. these methods include administering to the subject a therapeutically effective amount of cd8+ cd39+ cd103+ t lymphocytes. the present invention also relates to methods for isolating a nucleic acid encoding a t-lymphocyte receptor (tcr) that specifically binds a tumor cell antigen. these methods include isolating cd8+ cd39+ cd103+ t lymphocytes from a sample of an individual bearing a tumor expressing the tumor cell antigen, and cloning a nucleic acid molecule encoding a tcr from cd8+ cd39+ cd103+ t lymphocytes. further, the present invention relates to methods for expanding cd8+ cd39+ cd103+ t lymphocytes. in additional embodiments, the present invention pertains to methods for determining whether an individual bearing a tumor will respond to a checkpoint inhibitor. methods include detecting the presence of cd8+ cd39+ cd103+ t lymphocytes in a biological sample from an individual. |
| priorityDate |
2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |