| abstract |
Tumor-associated antigen-presenting constructs (taa) are provided herein comprising at least one innate stimulating receptor (isr) binding construct that binds to an isr expressed in an antigen-presenting cell (apc) and at least a cup binding construct that binds directly to a first cup that is physically associated with tumor cell derived material (tcdm) comprising one or more other cups. the isr-binding construct and the ta-binding construct are linked to each other, and the ta-presenting inducing construct induces a polyclonal t cell response to the first cup and to one or more other cups. methods of using the constructs that induce taa presentation, for example, in the treatment of cancer are also provided. |