Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c06d728f2a623a6264c98cd431958946 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2018-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4be05c0d453c913ce7994036d9b2bdc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421cc600b715be412fb5f3ce7f435cc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ffa308b502ebea9ecc2116727591a99 |
publicationDate |
2020-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
BR-112019017138-A2 |
titleOfInvention |
genome editing system and method |
abstract |
the present invention relates to a genome editing system for site-directed modification of a target sequence in the genome of a cell, which comprises a variant of the cas9 nuclease having greater specificity compared to the wild type cas9 nuclease or its expression construct, and an expression construct comprising the coding sequence for trna-grna fusion or ribozyme-grna fusion, or comprises an expression construct comprising the coding sequences for the nuclease variant cas9 and trna-grna or ribozyme- grna. a method is also provided to genetically modify a cell by introducing the genome editing system, which has high efficiency and high specificity. |
priorityDate |
2017-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |