| abstract |
The present invention relates to novel substituted n- (3-fluoropropyl) pyrrolidine compounds of formula (I-a): wherein R 1 and R 2 independently represent a hydrogen atom or a deuterium atom; a represents an oxygen atom or nitrogen atom; and serm-f represents a selective estrogen receptor modulator fragment comprising an aryl or heteroaryl group attached to the adjacent group "a". The invention also relates to the preparation and therapeutic uses of the compounds of formula (I-a) as estrogen receptor inhibitors and degraders. |